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Article

Effects of CYP2C19 Variants on Fluoxetine Metabolism in vitro.

Pharmacology - 1 Jan 2017

Fang Ping, He Jia-Yang, Han Ai-Xia, Lan Tian, Dai Da-Peng, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

AIMS: CYP2C19 is an important member of the cytochrome P450 enzyme superfamily. We recently identified 31 CYP2C19 alleles in the Han Chinese population. The aim of this study was to assess the catalytic activities of these allelic isoforms and their effects on the metabolism of fluoxetine in vitro. METHODS: The wild-type and 30 CYP2C19 variants were expressed in insect cells and each variant was characterized...

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PMID: 28494448
DOI: 10.1159/000475598

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