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Article

Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction.

Circulation research - 8 Dec 2017

Zhao Guizhen, Fu Yi, Cai Zeyu, Yu Fang, Gong Ze, Dai Rongbo, Hu Yanhua, Zeng Lingfang, Xu Qingbo, Kong Wei

Abstract excerpt

RATIONALE: Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) may confer vascular homeostasis and prevent aneurysmal disease. XBP1 (X-box binding protein 1), which exists in a...

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Source

Identifiers

PMID: 29089350
DOI: 10.1161/CIRCRESAHA.117.311450

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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