Article
MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression.
Life sciences - 1 Jan 2022
Si Xiaoyun, Chen Qixian, Zhang Jiechang, Zhou Wei, Chen Lijun, Chen Jingjing, Deng Na, Li Wei, Liu Danan, Wang Long, Shi Linyan, Sun Weihong, Song Haoyu, Zhong Lintao
Abstract excerpt
AIMS: Phenotypic switching of vascular smooth muscle cells (VSMCs) is essential for the formation of abdominal aortic aneurysms (AAAs). MicroRNA-23b (miR-23b) has recently been shown to play a vital role in maintaining the VSMC contractile phenotype; however, little is known about the role of miR-23b in the formation of AAAs. Here, we investigated whether miR-23b prevents AAA formation by inhibiting VSMC...
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