Article
Deletion of AT2 Receptor Prevents SHP-1-Induced VEGF Inhibition and Improves Blood Flow Reperfusion in Diabetic Ischemic Hindlimb.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2017
Paquin-Veillette Judith, Lizotte Farah, Robillard Stéphanie, Béland Raphaël, Breton Marc-André, Guay Andréanne, Despatis Marc-Antoine, Geraldes Pedro
Abstract excerpt
OBJECTIVE: Ischemia caused by narrowing of femoral artery is a major cause of peripheral arterial disease and morbidity affecting patients with diabetes mellitus. We have previously reported that the inhibition of the angiogenic response to VEGF (vascular endothelial growth factor) in diabetic mice was associated with the increased expression of SHP-1 (SH2 domain-containing phosphatase 1), a protein that can be...
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