Article
Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow.
Diabetes - 1 Jan 2013
Bhatwadekar Ashay D, Yan Yuanqing, Qi Xiaoping, Thinschmidt Jeffrey S, Neu Matthew B, Li Calzi Sergio, Shaw Lynn C, Dominiguez James M, Busik Julia V, Lee Choogon, Boulton Michael E, Grant Maria B
Abstract excerpt
In this study, we assessed whether Per2 clock gene-mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type control mice 4 and 12 months of age were used. To evaluate diabetes-like phenotype in Per2 mutant mice, retina was quantified for mRNA expression, and degree of diabetic retinopathy was evaluated. Bone marrow neuropathy was studied by staining femurs for...
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