Article
Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size.
Stroke - 1 Nov 2013
Li Qian, Atochin Dmitriy, Kashiwagi Satoshi, Earle John, Wang Annie, Mandeville Emiri, Hayakawa Kazuhide, d'Uscio Livius V, Lo Eng H, Katusic Zvonimir, Sessa William, Huang Paul L
Abstract excerpt
BACKGROUND AND PURPOSE: Phosphorylation of eNOS, an important post-translational modulator of its enzymatic activity, is reduced in diabetes mellitus. We hypothesized that modulation of eNOS phosphorylation could overcome diabetic vascular dysfunction and improves the outcome to stroke. METHODS:...
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