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Article

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2013

Ciccarelli Michele, Sorriento Daniela, Franco Antonietta, Fusco Anna, Del Giudice Carmine, Annunziata Roberto, Cipolletta Ersilia, Monti Maria Gaia, Dorn Gerald W, Trimarco Bruno, Iaccarino Guido

Abstract excerpt

OBJECTIVE: The role of endothelial G protein-coupled receptor kinase 2 (GRK2) was investigated in mice with selective deletion of the kinase in the endothelium (Tie2-CRE/GRK2(fl/fl)). APPROACH AND RESULTS: Aortas from Tie2-CRE/GRK2(fl/fl) presented functional and structural alterations as compared with control GRK2(fl/fl) mice. In particular, vasoconstriction was blunted to different agonists, and collagen and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23950144
DOI: 10.1161/ATVBAHA.113.302262
PMCID: PMC4262246

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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