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Article

Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice.

American journal of physiology. Cell physiology - 1 May 2018

Hayes Katherine L, Messina Louis M, Schwartz Lawrence M, Yan Jinglian, Burnside Amy S, Witkowski Sarah

Abstract excerpt

Peripheral artery disease is an atherosclerotic occlusive disease that causes limb ischemia and has few effective noninterventional treatments. Stem cell therapy is promising, but concomitant diabetes may limit its effectiveness. We evaluated the therapeutic potential of skeletal muscle pericytes to augment postischemic neovascularization in wild-type and type 2 diabetic (T2DM) mice. Wild-type C57BL/6J and leptin...

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Identifiers

PMID: 29351404
DOI: 10.1152/ajpcell.00158.2017
PMCID: PMC6008064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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