Article
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2014
Yuldasheva Nadira Y, Rashid Sheikh Tawqeer, Haywood Natalie J, Cordell Paul, Mughal Romana, Viswambharan Hema, Imrie Helen, Sukumar Piruthivi, Cubbon Richard M, Aziz Amir, Gage Matthew, Mbonye Kamatamu Amanda, Smith Jessica, Galloway Stacey, Skromna Anna, Scott D Julian A, Kearney Mark T, Wheatcroft Stephen B
Abstract excerpt
OBJECTIVES: Defective endothelial regeneration predisposes to adverse arterial remodeling and is thought to contribute to cardiovascular disease in type 2 diabetes mellitus. We recently demonstrated that the type 1 insulin-like growth factor receptor (IGF1R) is a negative regulator of insulin sensitivity and nitric oxide bioavailability. In this report, we examined partial deletion of the IGF1R as a potential...
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