Article
Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2002
Tamarat Radia, Silvestre Jean-Sébastien, Kubis Nathalie, Benessiano Joelle, Duriez Micheline, deGasparo Marc, Henrion Daniel, Levy Bernard I
Abstract excerpt
We assessed the role of angiotensin (Ang) II in ischemia-induced angiogenesis and analyzed the molecular pathways involved in such an effect. Ischemia was produced by unilateral artery femoral occlusion in control, in valsartan-treated (Ang II receptor type I antagonist, 20 mg/kg per day), in Ang II-treated (5 ng/kg per min), and in Ang II and valsartan-treated rats. After 28 days, angiogenesis was assessed by...
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