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Article

Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Dec 2010

Matsumoto Sachiko, Kamide Kei, Banno Fumiaki, Inoue Nobutaka, Mochizuki Naoki, Kawano Yuhei, Miyata Toshiyuki

Abstract excerpt

Regulator of G-protein signaling 2 (RGS2) negatively regulates the signaling of G-protein-coupled receptors, such as the angiotensin II (AngII) type 1 receptor by accelerating the inactivation of Gαq. Rgs2-deficient mice show increased sensitivity and prolonged responsiveness to vasoconstrictors, and genetic variations in the RGS2 gene are associated with hypertension in humans. This study aimed to clarify...

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Source

Identifiers

PMID: 20882024
DOI: 10.1038/hr.2010.184

Genes

RGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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