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Article

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.

Genes & development - 1 Oct 2017

Ilik Ibrahim Avsar, Maticzka Daniel, Georgiev Plamen, Gutierrez Noel Marie, Backofen Rolf, Akhtar Asifa

Abstract excerpt

The X chromosome provides an ideal model system to study the contribution of RNA-protein interactions in epigenetic regulation. In male flies, roX long noncoding RNAs (lncRNAs) harbor several redundant domains to interact with the ubiquitin ligase male-specific lethal 2 (MSL2) and the RNA helicase Maleless (MLE) for X-chromosomal regulation. However, how these interactions provide the mechanics of spreading...

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Topics

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Share to Chromosomal Proteins, Non-Histone
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dosage Compensation, Genetic

Share to Genetic Techniques

Share to Inverted Repeat Sequences

Share to Protein Domains

Share to RNA, Long Noncoding

Share to X Chromosome

Source

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Identifiers

PMID: 29066499
DOI: 10.1101/gad.304600.117
PMCID: PMC5710142

Genes

MSL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.PMID 29066499Read ↗

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.Semantic proximity Read ↗

ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins.Semantic proximity Read ↗

Structure-function analysis of the RNA helicase maleless.Semantic proximity Read ↗

The severity of roX1 mutations is predicted by MSL localization on the X chromosome.Semantic proximity Read ↗

Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase malelessSemantic proximity Read ↗

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Semantic proximity Read ↗

Local spreading of MSL complexes from roX genes on the Drosophila X chromosome.Semantic proximity Read ↗

RNA-dependent association of the Drosophila maleless protein with the male X chromosome.Semantic proximity Read ↗

Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.Semantic proximity Read ↗

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.Semantic proximity Read ↗

Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.Semantic proximity Read ↗

Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.Semantic proximity Read ↗

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