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Article

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.

Molecular and cellular biology - 1 Jul 2005

Morales Violette, Regnard Catherine, Izzo Annalisa, Vetter Irene, Becker Peter B

Abstract excerpt

The male-specific-lethal (MSL) proteins in Drosophila melanogaster serve to adjust gene expression levels in male flies containing a single X chromosome to equal those in females with a double dose of X-linked genes. Together with noncoding roX RNA, MSL proteins form the "dosage compensation complex" (DCC), which interacts selectively with the X chromosome to restrict the transcription-activating histone H4...

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Source

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Identifiers

PMID: 15988010
DOI: 10.1128/MCB.25.14.5947-5954.2005
PMCID: PMC1168827

Genes

MSL3
MSL1
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.PMID 15988010Read ↗

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.Semantic proximity Read ↗

Local spreading of MSL complexes from roX genes on the Drosophila X chromosome.Semantic proximity Read ↗

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.Semantic proximity Read ↗

ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins.Semantic proximity Read ↗

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.Semantic proximity Read ↗

The severity of roX1 mutations is predicted by MSL localization on the X chromosome.Semantic proximity Read ↗

Structure-function analysis of the RNA helicase maleless.Semantic proximity Read ↗

Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.Semantic proximity Read ↗

Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.Semantic proximity Read ↗

The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE.Semantic proximity Read ↗

RNA-DamID reveals cell-type-specific binding of roX RNAs at chromatin-entry sites.Semantic proximity Read ↗

Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.Semantic proximity Read ↗

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