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Article

Structure-function analysis of the RNA helicase maleless.

Nucleic acids research - 1 Feb 2008

Izzo Annalisa, Regnard Catherine, Morales Violette, Kremmer Elisabeth, Becker Peter B

Abstract excerpt

Loss of function of the RNA helicase maleless (MLE) in Drosophila melanogaster leads to male-specific lethality due to a failure of X chromosome dosage compensation. MLE is presumably involved in incorporating the non-coding roX RNA into the dosage compensation complex (DCC), which is an essential but poorly understood requirement for faithful targeting of the complex to the X chromosome. Sequence comparison...

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Identifiers

PMID: 18086708
DOI: 10.1093/nar/gkm1108
PMCID: PMC2241912

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structure-function analysis of the RNA helicase maleless.PMID 18086708Read ↗

ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins.Semantic proximity Read ↗

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.Semantic proximity Read ↗

RNA-dependent association of the Drosophila maleless protein with the male X chromosome.Semantic proximity Read ↗

Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase malelessSemantic proximity Read ↗

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.Semantic proximity Read ↗

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Semantic proximity Read ↗

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.Semantic proximity Read ↗

The severity of roX1 mutations is predicted by MSL localization on the X chromosome.Semantic proximity Read ↗

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.Semantic proximity Read ↗

Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.Semantic proximity Read ↗

Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.Semantic proximity Read ↗

Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.Semantic proximity Read ↗

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