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Article

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.

PloS one - 1 Jan 2015

Koya S Kiran, Meller Victoria H

Abstract excerpt

The ribonucleoprotein Male Specific Lethal (MSL) complex is required for X chromosome dosage compensation in Drosophila melanogaster males. Beginning at 3 h of development the MSL complex binds transcribed X-linked genes and modifies chromatin. A subset of MSL complex proteins, including MSL1 and MSL3, is also necessary for full expression of autosomal heterochromatic genes in males, but not females. Loss of the...

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Share to Dosage Compensation, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26468879
DOI: 10.1371/journal.pone.0140259
PMCID: PMC4607463

Genes

MSL3
MSL1

Provenance

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Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.PMID 26468879Read ↗

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Semantic proximity Read ↗

The severity of roX1 mutations is predicted by MSL localization on the X chromosome.Semantic proximity Read ↗

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.Semantic proximity Read ↗

Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.Semantic proximity Read ↗

Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.Semantic proximity Read ↗

Local spreading of MSL complexes from roX genes on the Drosophila X chromosome.Semantic proximity Read ↗

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.Semantic proximity Read ↗

RNA-dependent association of the Drosophila maleless protein with the male X chromosome.Semantic proximity Read ↗

Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.Semantic proximity Read ↗

Gene expression analysis of the function of the male-specific lethal complex in Drosophila.Semantic proximity Read ↗

ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins.Semantic proximity Read ↗

Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila.Semantic proximity Read ↗

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