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Article

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.

Molecular cell - 25 Jul 2013

Ilik Ibrahim Avsar, Quinn Jeffrey J, Georgiev Plamen, Tavares-Cadete Filipe, Maticzka Daniel, Toscano Sarah, Wan Yue, Spitale Robert C, Luscombe Nicholas, Backofen Rolf, Chang Howard Y, Akhtar Asifa

Abstract excerpt

Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and long noncoding RNAs (lncRNAs) for transcriptional upregulation of the male X chromosome. Here, by using UV crosslinking followed by deep sequencing, we show that two enzymes in the Male-Specific Lethal complex, MLE RNA helicase and MSL2 ubiquitin ligase, bind evolutionarily conserved domains containing tandem stem-loops in roX1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dosage Compensation, Genetic

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Source

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Identifiers

PMID: 23870142
DOI: 10.1016/j.molcel.2013.07.001
PMCID: PMC3804161

Genes

MSL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.PMID 23870142Read ↗

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Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males.Semantic proximity Read ↗

The MRG domain mediates the functional integration of MSL3 into the dosage compensation complex.Semantic proximity Read ↗

Structure-function analysis of the RNA helicase maleless.Semantic proximity Read ↗

The severity of roX1 mutations is predicted by MSL localization on the X chromosome.Semantic proximity Read ↗

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Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase malelessSemantic proximity Read ↗

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