Article
Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.
Science (New York, N.Y.) - 22 Nov 2002
Park Yongkyu, Kelley Richard L, Oh Hyangyee, Kuroda Mitzi I, Meller Victoria H
Abstract excerpt
The untranslated roX1 and roX2 RNAs are components of the Drosophila male-specific lethal (MSL) complex, which modifies histones to up-regulate transcription of the male X chromosome. roX genes are normally located on the X chromosome, and roX transgenes can misdirect the dosage compensation machinery to spread locally on other chromosomes. Here we define MSL protein abundance as a determinant of whether the MSL...
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