Article
Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.
Genesis (New York, N.Y. : 2000) - 1 Jan 2009
Deng Xinxian, Meller Victoria H
Abstract excerpt
Drosophila melanogaster males maintain a constant ratio of X-linked to autosomal gene products by increasing expression from their single X chromosome. This is achieved through the action of a complex composed of protein and roX RNA. This complex binds in the body of genes and increases expression through chromatin modification. The X-linked roX genes produce RNAs that are essential but redundant for recognition...
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