Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of dormant origins of DNA replication in budding yeast.

Genes & development - 15 Sept 1999

Santocanale C, Sharma K, Diffley J F

Abstract excerpt

Eukaryotic genomes often contain more potential replication origins than are actually used during S phase. The molecular mechanisms that prevent some origins from firing are unknown. Here we show that dormant replication origins on the left arm of budding yeast chromosome III become activated when both passive replication through them is prevented and the Mec1/Rad53 checkpoint that blocks late-origin firing is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to DNA Footprinting
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyurea

Share to Nocodazole

Share to Nucleic Acid Synthesis Inhibitors

Share to Protein Kinases

Share to Replication Origin

Source

Open in PubMed Open full text

Identifiers

PMID: 10500092
DOI: 10.1101/gad.13.18.2360
PMCID: PMC317032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of dormant origins of DNA replication in budding yeast.PMID 10500092Read ↗

Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.Semantic proximity Read ↗

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Semantic proximity Read ↗

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.Semantic proximity Read ↗

MRC1-dependent scaling of the budding yeast DNA replication timing program.Semantic proximity Read ↗

The spatial and temporal organization of origin firing during the S-phase of fission yeast.Semantic proximity Read ↗

Regulation of DNA-replication origins during cell-cycle progression.Semantic proximity Read ↗

Global early replication disrupts gene expression and chromatin conformation in a single cell cycleSemantic proximity Read ↗

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Semantic proximity Read ↗

The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae.Semantic proximity Read ↗

Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.Semantic proximity Read ↗

S-phase checkpoint activity and function throughout the cell cycleSemantic proximity Read ↗

The Cdc7 protein kinase is required for origin firing during S phase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.