Article
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
Brain : a journal of neurology - 1 Mar 2011
van der Zee Julie, Van Langenhove Tim, Kleinberger Gernot, Sleegers Kristel, Engelborghs Sebastiaan, Vandenberghe Rik, Santens Patrick, Van den Broeck Marleen, Joris Geert, Brys Jolien, Mattheijssens Maria, Peeters Karin, Cras Patrick, De Deyn Peter P, Cruts Marc, Van Broeckhoven Christine
Abstract excerpt
In a genome-wide association study of frontotemporal lobar degeneration with pathological inclusions of TAR DNA-binding protein, significant association was obtained with three single nucleotide polymorphisms at 7p21.3, in a region encompassing the gene TMEM106B. This study also suggested a potential modifying effect of TMEM106B on disease since the association was strongest in progranulin mutation carriers....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.