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Article

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2014

Lu Rui-Chun, Wang Hao, Tan Meng-Shan, Yu Jin-Tai, Tan Lan

Abstract excerpt

Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer's disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population...

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Identifiers

PMID: 24166182
DOI: 10.1007/s00702-013-1106-x

Genes

APOE

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