Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

doi:10.1093/brain/awaa141

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Article

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

Brain : a journal of neurology - 1 Jun 2020

Zhou Xiaolai, Nicholson Alexandra M, Ren Yingxue, Brooks Mieu, Jiang Peizhou, Zuberi Aamir, Phuoc Hung Nguyen, Perkerson Ralph B, Matchett Billie, Parsons Tammee M, Finch NiCole A, Lin Wenlang, Qiao Wenhui, Castanedes-Casey Monica, Phillips Virginia, Librero Ariston L, Asmann Yan, Bu Guojun, Murray Melissa E, Lutz Cathleen, Dickson Dennis W, Rademakers Rosa

Abstract excerpt

Genetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain ageing. In frontotemporal dementia (FTD), the high expressing TMEM106B risk haplotype was shown to increase susceptibility for FTD with TDP-43 inclusions (FTD-TDP) and to modify disease penetrance in progranulin mutation carriers (FTD-GRN). To elucidate the...

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PMID: 32504082
DOI: 10.1093/brain/awaa141
PMCID: PMC7296855

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