The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.

doi:10.1007/s00401-019-02066-0

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Article

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.

Acta neuropathologica - 1 Jan 2020

Li Zeran, Farias Fabiana H G, Dube Umber, Del-Aguila Jorge L, Mihindukulasuriya Kathie A, Fernandez Maria Victoria, Ibanez Laura, Budde John P, Wang Fengxian, Lake Allison M, Deming Yuetiva, Perez James, Yang Chengran, Bahena Jorge A, Qin Wei, Bradley Joseph L, Davenport Richard, Bergmann Kristy, Morris John C, Perrin Richard J, Benitez Bruno A, Dougherty Joseph D, Harari Oscar, Cruchaga Carlos

Abstract excerpt

Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex. The goal of this study is to investigate genetic factors associated with the neuronal proportion in health and disease. To identify cell-autonomous genetic variants associated with neuronal proportion in cortical tissues,...

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Identifiers

PMID: 31456032
DOI: 10.1007/s00401-019-02066-0
PMCID: PMC6942643

Genes

TMEM106B

Variants

rs3173615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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