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Article

A new mouse model for mania shares genetic correlates with human bipolar disorder.

PloS one - 1 Jan 2012

Saul Michael C, Gessay Griffin M, Gammie Stephen C

Abstract excerpt

Bipolar disorder (BPD) is a debilitating heritable psychiatric disorder. Contemporary rodent models for the manic pole of BPD have primarily utilized either single locus transgenics or treatment with psychostimulants. Our lab recently characterized a mouse strain termed Madison (MSN) that naturally displays a manic phenotype, exhibiting elevated locomotor activity, increased sexual behavior, and higher forced...

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Identifiers

PMID: 22675514
DOI: 10.1371/journal.pone.0038128
PMCID: PMC3366954

Genes

MSN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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