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Article

Human mood disorder risk gene Synaptotagmin-14 contributes to mania-like behaviors in mice.

Molecular psychiatry - 1 Aug 2025

Zhang Yue, Zhang Chu-Yi, Yuan Jing, Jiang Hongyan, Sun Ping, Hui Li, Xu Li, Yu Ling, Guo Zeyi, Wang Lu, Yang Yi, Li Ming, Li Shi-Wu, Yang Jianzhong, Li Wei, Teng Zhaowei, Xiao Xiao

Abstract excerpt

Bipolar disorder (BD) and major depressive disorder (MDD) are the most prevalent mood disorders and cause considerable burden worldwide. Compelling evidence suggests a pronounced overlap between these two disorders in clinical symptoms, treatment strategies, and genetic etiology. Here we leverage a BD GWAS (1822 cases and 4650 controls) and a MDD GWAS (5303 cases and 5337 controls), followed by independent...

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Identifiers

PMID: 39966626
DOI: 10.1038/s41380-025-02933-1

Genes

SYT14

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