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Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of <i>Shank3</i> mutant mice

2022-01-21

Abstract excerpt

Autism is characterised by atypical social communication and stereotyped behaviours. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1-2% of patients with autism and intellectual disability (ID), but the mechanisms underpinning the symptoms remain largely unknown. Here, we characterised the behaviour of Shank3 Δ11/Δ11 mice from three to twelve months of age. We observed decr...

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Literature Corpus work
5efb5e25-af76-58d1-bd65-7afe3b22a59d
DOI
10.1101/2022.01.19.476922
Open publication

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Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of <i>Shank3</i> mutant miceDOI 10.1101/2022.01.19.476922
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