Article
Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.
Genes, brain, and behavior - 1 Jul 2018
Blue E E, Yu C-E, Thornton T A, Chapman N H, Kernfeld E, Jiang N, Shively K M, Buckingham K J, Marvin C T, Bamshad M J, Bird T D, Wijsman E M
Abstract excerpt
The identification of novel genetic modifiers of age-at-onset (AAO) of Alzheimer's disease (AD) could advance our understanding of AD and provide novel therapeutic targets. A previous genome scan for modifiers of AAO among families affected by early-onset AD caused by the PSEN2 N141I variant identified 2 loci with significant evidence for linkage: 1q23.3 and 17p13.2. Here, we describe the fine-mapping of these 2...
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