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Article

A novel age-informed approach for genetic association analysis in Alzheimer's disease.

Alzheimer's research & therapy - 1 Apr 2021

Le Guen Yann, Belloy Michael E, Napolioni Valerio, Eger Sarah J, Kennedy Gabriel, Tao Ran, He Zihuai, Greicius Michael D

Abstract excerpt

BACKGROUND: Many Alzheimer's disease (AD) genetic association studies disregard age or incorrectly account for it, hampering variant discovery. METHODS: Using simulated data, we compared the statistical power of several models: logistic regression on AD diagnosis adjusted and not adjusted for age; linear regression on a score integrating case-control status and age; and multivariate Cox regression on...

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Identifiers

PMID: 33794991
DOI: 10.1186/s13195-021-00808-5
PMCID: PMC8017764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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