Article
Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease.
Molecular psychiatry - 1 Nov 2015
Lalli M A, Bettcher B M, Arcila M L, Garcia G, Guzman C, Madrigal L, Ramirez L, Acosta-Uribe J, Baena A, Wojta K J, Coppola G, Fitch R, de Both M D, Huentelman M J, Reiman E M, Brunkow M E, Glusman G, Roach J C, Kao A W, Lopera F, Kosik K S
Abstract excerpt
We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onset...
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