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Article

Combined epigenetic/genetic study identified an ALS age of onset modifier.

Acta neuropathologica communications - 23 Apr 2021

Zhang Ming, Xi Zhengrui, Saez-Atienzar Sara, Chia Ruth, Moreno Danielle, Sato Christine, Montazer Haghighi Mahdi, Traynor Bryan J, Zinman Lorne, Rogaeva Ekaterina

Abstract excerpt

Age at onset of amyotrophic lateral sclerosis (ALS) is highly variable (eg, 27-74 years in carriers of the G4C2-expansion in C9orf72). It might be influenced by environmental and genetic factors via the modulation of DNA methylation (DNAm) at CpG-sites. Hence, we combined an epigenetic and genetic approach to test the hypothesis that some common single nucleotide polymorphisms (SNPs) at CpG-sites (CpG-SNPs) could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33892821
DOI: 10.1186/s40478-021-01183-w
PMCID: PMC8066440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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