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Article

Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2023

Li Yi-Ju, Nuytemans Karen, La Jong Ok, Jiang Rong, Slifer Susan H, Sun Shuming, Naj Adam, Gao Xiaoyi Raymond, Martin Eden R

Abstract excerpt

INTRODUCTION: Our understanding of the genetic predisposition for age-at-onset (AAO) of Alzheimer's disease (AD) is limited. Here, we sought to identify genes modifying AAO and examined whether any have sex-specific effects. METHODS: Genome-wide association analysis were performed on imputed genetic data of 9219 AD cases and 10,345 controls from 20 cohorts of the Alzheimer's Disease Genetics Consortium. AAO was...

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PMID: 36738287
DOI: 10.1002/alz.12927

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