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Article

RBFOX1 association with age at onset of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Xicota Laura, Cheng Rong, Andersen Stacy L, Zmuda Joseph M, Wojczynski Mary, Feitosa Mary F, Bradley Joseph, Cruchaga Carlos, Contreras Alex G, Hohman Timothy J, Reyes-Dumeyer Dolly, Vardarajan Badri V, Cosentino Stephanie, Mayeux Richard, Lee Joseph H, Barral Sandra

Abstract excerpt

INTRODUCTION: Genetic contributors to early onset Alzheimer's disease (AD) beyond APP and PSEN1/2 remain unknown. Identifying novel loci may reveal disease mechanisms and therapeutic targets. We investigated genetic variants influencing age at onset in early onset families from the Long-Life Family Study (LLFS). METHODS: Six families with at least two early onset cases (onset ≤ 65) were identified among 3476 LLFS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Linkage

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to RNA Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 41724706
DOI: 10.1002/alz.71188
PMCID: PMC12928012

Genes

RBFOX1
APP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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