Article
Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.
JAMA neurology - 1 Sept 2015
Lee Joseph H, Cheng Rong, Vardarajan Badri, Lantigua Rafael, Reyes-Dumeyer Dolly, Ortmann Ward, Graham Robert R, Bhangale Tushar, Behrens Timothy W, Medrano Martin, Jiménez-Velázquez Ivonne Z, Mayeux Richard
Abstract excerpt
IMPORTANCE: The present study identified potential genetic modifiers that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onset in PSEN1 mutation carrier families, and further investigation of these modifiers may provide insight into the pathobiology of AD and potential therapeutic measures. OBJECTIVE: To identify genetic variants that modify age at onset of AD. DESIGN,...
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