Article
Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells.
Circulation research - 10 Nov 2017
Yang Libang, Gao Ling, Nickel Thomas, Yang Jing, Zhou Jingyi, Gilbertsen Adam, Geng Zhaohui, Johnson Caitlin, Young Bernice, Henke Craig, Gourley Glenn R, Zhang Jianyi
Abstract excerpt
RATIONALE: The phenotypes of vascular smooth muscle cells (vSMCs) comprise a continuum bounded by predominantly contractile and synthetic cells. Some evidence suggests that contractile vSMCs can assume a more synthetic phenotype in response to ischemic injury, but the mechanisms that activate this phenotypic switch are poorly understood. OBJECTIVE: To determine whether lactate, which increases in response to...
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