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Article

SCD1 deficiency alters the perivascular secretory function of adipocytes and induces phenotypic changes in vascular smooth muscle cells.

Biochemical pharmacology - 1 Mar 2026

Sowka Adrian, Balatskyi Volodymyr V, Navrulin Viktor O, Ntambi James M, Dobrzyn Pawel

Abstract excerpt

Perivascular adipose tissue (PVAT) maintains vascular homeostasis by secreting vasoactive factors that interact with vascular smooth muscle cells (VSMCs). VSMCs maintaining the structure and function of blood vessels through their contractile phenotype. Under pathological conditions, the secretory function of PVAT changes from homeostatic to harmful. For this reason, VSMCs may undergo a phenotypic shift toward a...

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PMID: 41391694
DOI: 10.1016/j.bcp.2025.117633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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