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Article

MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2015

Rodríguez Andrés I, Csányi Gábor, Ranayhossaini Daniel J, Feck Douglas M, Blose Kory J, Assatourian Lillian, Vorp David A, Pagano Patrick J

Abstract excerpt

OBJECTIVE: Blood vessel hemodynamics have profound influences on function and structure of vascular cells. One of the main mechanical forces influencing vascular smooth muscle cells (VSMC) is cyclic stretch (CS). Increased CS stimulates reactive oxygen species (ROS) production in VSMC, leading to their dedifferentiation, yet the mechanisms involved are poorly understood. This study was designed to test the...

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Identifiers

PMID: 25550204
DOI: 10.1161/ATVBAHA.114.304936
PMCID: PMC4409426

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