Article

Lactate promotes cardiomyocyte dedifferentiation through metabolic reprogramming

2020-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Cardiomyocytes undergo different metabolic changes during development and differentiation crucial for their maturation and adult function, such as contraction, growth and survival. Alterations of cardiac metabolism have been associated with multiple disease states and pathological hypertrophy. The shift in substrate preference can impair the stress response, but it may also have a role in cell g...

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Literature Corpus work: 906fdcbc-91c6-5bcb-ae82-3cbccd72aa8c
DOI: 10.1101/2020.07.21.213736

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