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Article

Role of ROS-TRPM7-ERK1/2 axis in high concentration glucose-mediated proliferation and phenotype switching of rat aortic vascular smooth muscle cells.

Biochemical and biophysical research communications - 16 Dec 2017

Yang Meimei, Fang Jing, Liu Qingan, Wang Yan, Zhang Zhuobo

Abstract excerpt

This study investigated the change of transient receptor potential cation channel subfamily M member 7 (TRPM7) expression in rat aortic vascular smooth muscle cells (RAoSMCs) treated with a high concentration of d-glucose (HG) and its role in promoting the proliferative phenotype of RAoSMCs. Chronic exposure to HG increased TRPM7 protein expression and TRPM7 whole-cell currents in RAoSMCs. By contrast, RAoSMC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29079194
DOI: 10.1016/j.bbrc.2017.10.122

Genes

TRPM7

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