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Article

Vascular smooth muscle cell phenotypic transition regulates gap junctions of cardiomyocyte.

Heart and vessels - 1 Jul 2020

Zhou En, Zhang Tiantian, Bi Changlong, Wang Changqian, Zhang Zongqi

Abstract excerpt

Atrial fibrillation (AF) is one of the most prevalent arrhythmias. Myocardial sleeves of the pulmonary vein are critical in the occurrence of AF. Our study aims to investigate the effect of synthetic vascular smooth muscle cells (SMCs) on gap junction proteins in cardiomyocytes. (1) Extraction of vascular SMCs from the pulmonary veins of Norway rats. TGF-β1 was used to induce the vascular SMCs switching to the...

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Cell Communication
Cell Plasticity
Coculture Techniques
Connexin 43
Gap Junction alpha-5 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Pulmonary Veins

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Identifiers

PMID: 32270355
DOI: 10.1007/s00380-020-01602-3
PMCID: PMC7256098

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