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Article

Relaxin-3/RXFP1 Axis Regulates the Phenotypic Switch of Diabetic Vascular Smooth Muscle Cells by Inhibiting H3K18la-Mediated Egfr Transcription.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2026

Xue Jiaxin, Wang Jingzhi, Yang Yuxin, Liang Xinfang, Liu Xiaoqi, Hong Siting, Ma Xiao, Zhang Xiaohui

Abstract excerpt

BACKGROUND: The phenotypic switching of vascular smooth muscle cells (VSMCs) is a critical pathophysiological mechanism of diabetic vascular remodeling. There is increasing evidence indicating that endogenous relaxin-3 exhibits cardiovascular effects, including vasodilation, reversal of ventricular remodeling, and attenuation of myocardial fibrosis. This study investigates the role of relaxin-3 as a key regulator...

Read the complete abstract on PubMed

Topics

Animals
Muscle, Smooth, Vascular
Phenotype
Myocytes, Smooth Muscle
Receptors, G-Protein-Coupled

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Relaxin

Male

Histones

ErbB Receptors

Humans

Signal Transduction

Transcription, Genetic

Cells, Cultured

Diabetes Mellitus, Experimental

Rats, Sprague-Dawley

Receptors, Peptide

Vascular Remodeling

Nerve Tissue Proteins

Source

Identifiers

PMID: 42657465
DOI: 10.1161/ATVBAHA.126.324338

Genes

RXFP1
LDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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