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Article

Mitochondrial influences on smooth muscle phenotype.

American journal of physiology. Cell physiology - 1 Feb 2024

Pearce William J

Abstract excerpt

Smooth muscle cells transition reversibly between contractile and noncontractile phenotypes in response to diverse influences, including many from mitochondria. Numerous molecules including myocardin, procontractile miRNAs, and the mitochondrial protein prohibitin-2 promote contractile differentiation; this is opposed by mitochondrial reactive oxygen species (mtROS), high lactate concentrations, and metabolic...

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Identifiers

PMID: 38009196
DOI: 10.1152/ajpcell.00354.2023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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