Article

Lactate drives maladaptive metabolic reprogramming via MRS2 inischemia–reperfusion-induced acute kidney injury

2026-02-24

Abstract excerpt

<title>Abstract</title> <p> Background Ischemia–reperfusion–induced acute kidney injury (I/R-AKI) causes profound bioenergetic collapse in renal proximal tubular epithelial cells, triggering a sustained shift from mitochondrial oxidative metabolism to glycolysis. Although lactate accumulation is a hallmark of this metabolic state, whether lactate actively drives mitochondrial dysfunction and enforces persistent...

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Literature Corpus work: fce52364-524a-55d7-8ef8-15f72f6505ae
DOI: 10.21203/rs.3.rs-8846937/v1

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