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Article

Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.

Molecular therapy : the journal of the American Society of Gene Therapy - 3 Jan 2018

Amatya Christina, Radichev Ilian A, Ellefson Jacob, Williams Mark, Savinov Alexei Y

Abstract excerpt

Type 1 diabetes (T1D) is characterized by massive destruction of insulin-producing β cells by autoreactive T lymphocytes, arising via defective immune tolerance. Therefore, effective anti-T1D therapeutics should combine autoimmunity-preventing and insulin production-restoring properties. We constructed a cell-permeable PDX1-FOXP3-TAT fusion protein (FP) composed of two transcription factors: forkhead box P3...

Read the complete abstract on PubMed

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Secreting Cells

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Share to Mice, Inbred NOD

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Source

Open in PubMed Open full text

Identifiers

PMID: 28988715
DOI: 10.1016/j.ymthe.2017.08.014
PMCID: PMC5762970

Genes

FOXP3
PDX1
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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