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Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8 <sup>+</sup> T cell exhaustion

2025-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stem/stromal cell (MSC) therapy holds great promise as both a therapeutic option and as a biofactory, as cells produce therapeutic proteins to augment their efficacy in disease treatment. This study investigates the therapeutic effects and the mechanistic insights of alpha-1 antitrypsin overexpressing MSCs (AAT-MSCs) in diabetes prevention and treatment. A single infusion of AAT-MSCs...

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Literature Corpus work: 12693e02-1017-5a60-be17-fac17162147d
DOI: 10.1101/2025.04.19.649667

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