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Article

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.

Science translational medicine - 11 Dec 2013

Passerini Laura, Rossi Mel Eva, Sartirana Claudia, Fousteri Georgia, Bondanza Attilio, Naldini Luigi, Roncarolo Maria Grazia, Bacchetta Rosa

Abstract excerpt

In humans, mutations in the gene encoding for forkhead box P3 (FOXP3), a critically important transcription factor for CD4⁺CD25⁺ regulatory T (T(reg)) cell function, lead to a life-threatening systemic poly-autoimmune disease, known as immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Severe autoimmunity results from the inborn dysfunction and instability of FOXP3-mutated T(reg)...

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Identifiers

PMID: 24337481
DOI: 10.1126/scitranslmed.3007320

Genes

FOXP3

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