Article

ENTPD3-specific CAR regulatory T cells for local immune control in T1D

2024-11-15

Abstract excerpt

Despite advances in Type 1 Diabetes (T1D) management such as hybrid closed loop systems, patients still face significant morbidity, reduced life expectancy, and impaired glucose regulation compared to healthy individuals or those with pancreas transplants. Here we developed beta cell-specific Chimeric Antigen Receptors (CAR) targeting the antigen ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3) using a no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 852d302f-f133-522b-b505-a3951cbd1a06
DOI: 10.1101/2024.11.12.622951

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ENTPD3-specific CAR regulatory T cells for local immune control in T1DDOI 10.1101/2024.11.12.622951Read

Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirectionSemantic proximity Read

Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptidesSemantic proximity Read

Using the T Cell Receptor as a Biomarker in Type 1 Diabetes.Semantic proximity Read

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.Semantic proximity Read

Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 DiabetesSemantic proximity Read

Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice.Semantic proximity Read

Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetesSemantic proximity Read

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cellsSemantic proximity Read

Genome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function.Semantic proximity Read

Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4 <sup>+</sup> T cellsSemantic proximity Read

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.Semantic proximity Read

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 DiabetesSemantic proximity Read