Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Therapeutic Strategies to Restore Regulatory T Cell Control of Islet Autoimmunity in Type 1 Diabetes.

Frontiers in immunology - 1 Jan 2021

Volfson-Sedletsky Victoria, Jones Albert, Hernandez-Escalante Jaileene, Dooms Hans

Abstract excerpt

Despite many decades of investigation uncovering the autoimmune mechanisms underlying Type 1 Diabetes (T1D), translating these findings into effective therapeutics has proven extremely challenging. T1D is caused by autoreactive T cells that become inappropriately activated and kill the β cells in the pancreas, resulting in insulin insufficiency and hyperglycemia. A large body of evidence supports the idea that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Islets of Langerhans

Share to Phenotype

Share to Receptors, Chimeric Antigen

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 33815387
DOI: 10.3389/fimmu.2021.635767
PMCID: PMC8015774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Therapeutic Strategies to Restore Regulatory T Cell Control of Islet Autoimmunity in Type 1 Diabetes.PMID 33815387Read ↗

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and AutoimmunitySemantic proximity Read ↗

Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers.Semantic proximity Read ↗

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.Semantic proximity Read ↗

Developmental Heterogeneity of Foxp3⁺ Regulatory T Cells in the Orchestration of Metabolic HomeostasisSemantic proximity Read ↗

Developmental Heterogeneity of Foxp3⁺ Regulatory T Cells in the Orchestration of Metabolic HomeostasisSemantic proximity Read ↗

Dysfunction of regulatory T cells in pathogenesis of type 1 diabetes mellitusSemantic proximity Read ↗

Administration of CD4+CD25highCD127− Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in ChildrenSemantic proximity Read ↗

Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and ChallengesSemantic proximity Read ↗

Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes.Semantic proximity Read ↗

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application.Semantic proximity Read ↗

Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice.Semantic proximity Read ↗

CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.