Article

Epithelial FOXP3 Drives Pancreatic Fibrosis through O-glycosylated IL-6

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND & AIMS</h4> The transcription factor FOXP3, known for specifying regulatory T cell fate, is unexpectedly expressed in the epithelium of precancerous pancreatic lesions. Here we investigate its non-immune role in initiating pancreatic fibrosis, a process driving therapeutic resistance and organ failure in pancreatic ductal adenocarcinoma (PDAC) with unknown origins in early neopla...

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Literature Corpus work: 0ebc0510-90f0-5b41-9acb-e341368b784e
DOI: 10.1101/2025.11.19.689208

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