Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

doi:10.1038/mp.2017.193

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Article

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

Molecular psychiatry - 1 Sept 2018

Hancock D B, Guo Y, Reginsson G W, Gaddis N C, Lutz S M, Sherva R, Loukola A, Minica C C, Markunas C A, Han Y, Young K A, Gudbjartsson D F, Gu F, McNeil D W, Qaiser B, Glasheen C, Olson S, Landi M T, Madden P A F, Farrer L A, Vink J, Saccone N L, Neale M C, Kranzler H R, McKay J, Hung R J, Amos C I, Marazita M L, Boomsma D I, Baker T B, Gelernter J, Kaprio J, Caporaso N E, Thorgeirsson T E, Hokanson J E, Bierut L J, Stefansson K, Johnson E O

Abstract excerpt

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling...

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Identifiers

PMID: 28972577
DOI: 10.1038/mp.2017.193
PMCID: PMC5882602

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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