Article
Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2009
Hoft Nicole R, Corley Robin P, McQueen Matthew B, Schlaepfer Isabel R, Huizinga David, Ehringer Marissa A
Abstract excerpt
Neuronal nicotinic acetylcholine receptors are activated by both endogenous acetylcholine and exogenous nicotine, making sequence variations in these receptors likely candidates for association with tobacco phenotypes. Previous studies have found evidence for significant association between single nucleotide polymorphisms (SNPs) in the genomic region containing the CHRNA6 and CHRNB3 genes and tobacco behaviors....
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